Review
Regulatory T cells and their role in rheumatic diseases: a potential target for novel therapeutic development
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* Corresponding author: Diana Milojevic milojevic@peds.ucsf.edu
- † Equal contributors
1 Department of Pediatrics, UCSF, San Francisco, CA 94143, USA
2 Department of Pediatrics, Stanford University, Stanford, CA 94305, USA
Pediatric Rheumatology 2008, 6:20 doi:10.1186/1546-0096-6-20
Published: 1 December 2008Abstract
Regulatory T cells have an important role in limiting immune reactions and are essential regulators of self-tolerance. Among them, CD4+CD25high regulatory T cells are the best-described subset. In this article, we summarize current knowledge on the phenotype, function, and development of CD4+CD25high regulatory T cells. We also review the literature on the role of these T cells in rheumatic diseases and discuss the potential for their use in immunotherapy.