Pediatric Rheumatology
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 ReviewRegulatory T cells and their role in rheumatic diseases: a potential target for novel therapeutic developmentDiana Milojevic1* , Khoa D Nguyen2* , Diane Wara1 and Elizabeth D Mellins2  1
Department of Pediatrics, UCSF, San Francisco, CA 94143, USA 2
Department of Pediatrics, Stanford University, Stanford, CA 94305, USA author email corresponding author email* Contributed equally
Pediatric Rheumatology 2008,
6:20doi:10.1186/1546-0096-6-20
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| Published: |
1 December 2008 |
Abstract
Regulatory T cells have an important role in limiting immune reactions and are essential regulators of self-tolerance. Among them, CD4+CD25high regulatory T cells are the best-described subset. In this article, we summarize current knowledge on the phenotype, function, and development of CD4+CD25high regulatory T cells. We also review the literature on the role of these T cells in rheumatic diseases and discuss the potential for their use in immunotherapy. |