Regulatory T cells and their role in rheumatic diseases: a potential target for novel therapeutic development

doi:10.1186/1546-0096-6-20

Pediatric Rheumatology

Volume 6

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Regulatory T cells and their role in rheumatic diseases: a potential target for novel therapeutic development

Diana Milojevic¹^* , Khoa D Nguyen²^* , Diane Wara¹ and Elizabeth D Mellins²

¹Department of Pediatrics, UCSF, San Francisco, CA 94143, USA

²Department of Pediatrics, Stanford University, Stanford, CA 94305, USA

author email corresponding author email* Contributed equally

Pediatric Rheumatology 2008, 6:20doi:10.1186/1546-0096-6-20


Published:	1 December 2008

Abstract

Regulatory T cells have an important role in limiting immune reactions and are essential regulators of self-tolerance. Among them, CD4+CD25^highregulatory T cells are the best-described subset. In this article, we summarize current knowledge on the phenotype, function, and development of CD4+CD25^highregulatory T cells. We also review the literature on the role of these T cells in rheumatic diseases and discuss the potential for their use in immunotherapy.