This article is part of the supplement: 15th Paediatric Rheumatology European Society (PreS) Congress . Poster presentationCD39: a regulatory role in childhood arthritisInstitute of Child Health, UCL, London, UK
from 15th Paediatric Rheumatology European Society (PreS) Congress Pediatric Rheumatology 2008, 6(Suppl 1):P10doi:10.1186/1546-0096-6-S1-P10
First paragraph (this article has no abstract)Human regulatory T cells (T reg) are classically defined as CD4+ CD25hi Foxp3+. There is increasing evidence that T cells may be subject to regulation via the conversion of proinflammatory ATP to anti-inflammatory adenosine. Methotrexate, the standard therapy for children with JIA, is proposed to work via this mechanism. CD39 belongs to a family of ectoenzymes that convert ATP into an adenosine precursor. ATPase activity may therefore represent an important regulatory mechanism in JIA. |




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