CD39: a regulatory role in childhood arthritis

doi:10.1186/1546-0096-6-S1-P10

Pediatric Rheumatology

Volume 6
Suppl 1

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Moncrieffe H
Nistala K
Hunter P
Kamhieh Y
Wedderburn L

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Nistala K
Hunter P
Kamhieh Y
Wedderburn L
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This article is part of the supplement: 15th Paediatric Rheumatology European Society (PreS) Congress .

Poster presentation

CD39: a regulatory role in childhood arthritis

H Moncrieffe, K Nistala, P Hunter, Y Kamhieh and L Wedderburn

Institute of Child Health, UCL, London, UK

corresponding author email

from 15^thPaediatric Rheumatology European Society (PreS) Congress
London, UK. 14–17 September 2008

Pediatric Rheumatology 2008, 6(Suppl 1):P10doi:10.1186/1546-0096-6-S1-P10


Published:	15 September 2008

First paragraph (this article has no abstract)

Human regulatory T cells (T reg) are classically defined as CD4+ CD25hi Foxp3+. There is increasing evidence that T cells may be subject to regulation via the conversion of proinflammatory ATP to anti-inflammatory adenosine. Methotrexate, the standard therapy for children with JIA, is proposed to work via this mechanism. CD39 belongs to a family of ectoenzymes that convert ATP into an adenosine precursor. ATPase activity may therefore represent an important regulatory mechanism in JIA.