This article is part of the supplement: 15th Paediatric Rheumatology European Society (PreS) Congress .

Poster presentation

The TRAF1/C5 region is a risk factor for polyarthritis in juvenile idiopathic arthritis

HM Albers¹, FAS Kurreeman¹, JJ Houwing-Duistermaat¹, DMC Brinkman¹, SSM Kamphuis², HJ Girschick³, C Wouters⁴, MAJ van Rossum⁵, W Verduyn¹, REM Toes¹, TWJ Huizinga¹, MW Schilham¹ and R ten Cate¹

¹  Leiden University Medical Center, Leiden, Netherlands

²  Erasmus Medical Center – Sophia Children's Hospital, Rotterdam, Netherlands

³  University of Wuerzburg, Wuerzburg, Germany

⁴  University Hospital Gasthuisberg, Leuven, Belgium

⁵  Emma Children's Hospital AMC, Amsterdam, Netherlands

corresponding author email

from 15^th Paediatric Rheumatology European Society (PreS) Congress
London, UK. 14–17 September 2008

Pediatric Rheumatology 2008, 6(Suppl 1):P11doi:10.1186/1546-0096-6-S1-P11

The electronic version of this abstract is the complete one and can be found online at: http://www.ped-rheum.com/content/6/S1/P11

Published:

15 September 2008

© 2008 Albers et al; licensee BioMed Central Ltd.

Background

Juvenile idiopathic arthritis (JIA) is a chronic disorder in which both genetic and environmental factors are involved. Recently we identified the TRAF1/C5 region (located on chromosome 9q33-34) as a risk factor for rheumatoid arthritis (RA) (p_combined = 1.4 × 10^-8) [1]. In the present study the association of the TRAF1/C5 region with the susceptibility to JIA was investigated.

Methods

A case-control association study was performed in 338 Caucasian JIA patients and 511 healthy individuals. We genotyped SNP rs10818488 as a marker for the TRAF1/C5 region.

Results

The A-allele was associated with the susceptibility to Rheumatoid Factor (RF) negative polyarthritis with an 11% increase in allele frequency (OR 1.54, 95% CI 1.09–2.18; p = 0.012). This association was stronger when combining subtypes with a polyarticular phenotype (OR 1.46, 95% CI 1.12–1.90; p = 0.004). In addition, we observed a trend towards an increase in A-allele frequency in patients with extended oligoarthritis versus persistent oligoarthritis (49% and 38% respectively); p = 0.055.

Conclusion

Apart from being a well replicated risk factor for RA, TRAF1/C5 also appears to be a risk factor for the RF negative polyarthritis subtype of JIA and, more generally, seems to be associated with subtypes of JIA characterized by a polyarticular course.

References

1. Kurreeman FA, Padyukov L, Marques RB, Schrodi SJ, Seddighzadeh M, Stoeken-Rijsbergen G, Helm-van Mil AH, Allaart CF, Verduyn W, Houwing-Duistermaat J, et al.: A candidate gene approach identifies the TRAF1/C5 region as a risk factor for rheumatoid arthritis.

   PLoS Med 2007, 4:e278. PubMed Abstract | Publisher Full Text | PubMed Central Full Text

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