Pediatric Rheumatology

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This article is part of the supplement: 15th Paediatric Rheumatology European Society (PreS) Congress

Open Access Poster presentation

The role of synovial fluid cytokines IL-6, IL-23 and IL-17 in the pathogenesis and persistence of synovial inflammation in JIA patients

V Tzimouli1*, M Trachana1, A Taparkou1, P Pratsidou-Gertsi1, S Metsovitis2, G Pardalos1 and F Kanakoudi-Tsakalidou1

  • * Corresponding author: V Tzimouli

Author Affiliations

1 Pediatric Immunology and Rheumatology Referral Center, First Department of Pediatrics, Aristotle University, Thessaloniki, Greece

2 Department of Orthopaedics, Ippokration General Hospital, Thessaloniki, Greece

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Pediatric Rheumatology 2008, 6(Suppl 1):P12 doi:10.1186/1546-0096-6-S1-P12

Published: 15 September 2008

First paragraph (this article has no abstract)

Recent data in adult Rheumatoid Arthritis support that the Th17 cell-derived cytokine interleukin 17 (IL-17) in the presence of IL-6 and IL-23 plays a critical role in the pathogenesis of chronic destructive arthritis. Data on synovial fluid (SF) concentrations of IL-17 in JIA pts are sparse. We measured concentrations of the above 3 cytokines and assessed the CD4+CD25highFoxP3+ (Treg) and CD4+CD25lowFoxP3- T cell subpopulations in the SF of children with JIA. Findings were correlated with SF sRANKL which expresses the osteoclastic activity in active disease.