This article is part of the supplement: 15th Paediatric Rheumatology European Society (PreS) Congress .

Poster presentation

The role of synovial fluid cytokines IL-6, IL-23 and IL-17 in the pathogenesis and persistence of synovial inflammation in JIA patients

V Tzimouli¹, M Trachana¹, A Taparkou¹, P Pratsidou-Gertsi¹, S Metsovitis², G Pardalos¹ and F Kanakoudi-Tsakalidou¹

¹  Pediatric Immunology and Rheumatology Referral Center, First Department of Pediatrics, Aristotle University, Thessaloniki, Greece

²  Department of Orthopaedics, Ippokration General Hospital, Thessaloniki, Greece

corresponding author email

from 15^th Paediatric Rheumatology European Society (PreS) Congress
London, UK. 14–17 September 2008

Pediatric Rheumatology 2008, 6(Suppl 1):P12doi:10.1186/1546-0096-6-S1-P12

Published:	15 September 2008

First paragraph (this article has no abstract)

Recent data in adult Rheumatoid Arthritis support that the Th17 cell-derived cytokine interleukin 17 (IL-17) in the presence of IL-6 and IL-23 plays a critical role in the pathogenesis of chronic destructive arthritis. Data on synovial fluid (SF) concentrations of IL-17 in JIA pts are sparse. We measured concentrations of the above 3 cytokines and assessed the CD4+CD25^highFoxP3+ (Treg) and CD4+CD25^lowFoxP3- T cell subpopulations in the SF of children with JIA. Findings were correlated with SF sRANKL which expresses the osteoclastic activity in active disease.