Pediatric Rheumatology

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This article is part of the supplement: 15th Paediatric Rheumatology European Society (PreS) Congress

Open Access Poster presentation

The Damage Associated Molecular Pattern (DAMP) molecule S100A12 induces pro-inflammatory responses in monocytes via innate immunity signalling pathways

H Wittkowski1*, D Viemann1, A Lueken2, K Barczyk2, T Vogl2, J Roth2 and D Foell1

  • * Corresponding author: H Wittkowski

Author Affiliations

1 University Hospital Muenster, Department of Pediatrics, Muenster, Germany

2 University Hospital Muenster, Institute of Immunology, Muenster, Germany

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Pediatric Rheumatology 2008, 6(Suppl 1):P2 doi:10.1186/1546-0096-6-S1-P2

Published: 15 September 2008

First paragraph (this article has no abstract)

In a previous study, we demonstrated excessive activation of neutrophils leading to high concentrations of S100A12, a member of the damage-associated molecular pattern molecules (DAMP), in systemic-onset juvenile idiopathic arthritis (SOJIA) which is not found in other inflammatory diseases. Binding to the Receptor for Advanced Glycation Endproducts (RAGE) has been shown but exact molecular mechanisms of S100A12 leading to pro-inflammatory responses in immune cells are still lacking.