Tumor necrosis factor-alpha polymorphism and susceptibility to juvenile idiopathic arthritis

doi:10.1186/1546-0096-6-S1-P6

Pediatric Rheumatology

Volume 6
Suppl 1

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Kasapcopur O
Arisoy N
Batar B
Guven M

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Arisoy N
Batar B
Guven M
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This article is part of the supplement: 15th Paediatric Rheumatology European Society (PreS) Congress .

Poster presentation

Tumor necrosis factor-alpha polymorphism and susceptibility to juvenile idiopathic arthritis

S Bayraktar, O Kasapcopur, N Arisoy, B Batar and M Guven

Istanbul University, Cerrahpasa Medical School, Istanbul, Turkey

corresponding author email

from 15^thPaediatric Rheumatology European Society (PreS) Congress
London, UK. 14–17 September 2008

Pediatric Rheumatology 2008, 6(Suppl 1):P6doi:10.1186/1546-0096-6-S1-P6


Published:	15 September 2008

First paragraph (this article has no abstract)

Juvenile idiopathic arthritis (JIA) is a complex, multifactorial and chronic inflammatory disease of unknown etiology with considerable variability in which tumor necrosis factor-alpha (TNF-α) plays an important role. Both genetic and environmental factors can contribute to a susceptibility to disease initiation as well as a severity of disease course. TNF-α polymorphisms may be an independent marker of susceptibility and severity of JIA. The aim of this study was to elucidate putative association between the -863 C/A polymorphism in the promoter region of the TNF-a gene and susceptibility to onset and severity of JIA.