This article is part of the supplement: 15th Paediatric Rheumatology European Society (PreS) Congress
Poster presentation
Tumor necrosis factor-alpha polymorphism and susceptibility to juvenile idiopathic arthritis
Pediatric Rheumatology 2008, 6(Suppl 1):P6 doi:10.1186/1546-0096-6-S1-P6
Published: 15 September 2008First paragraph (this article has no abstract)
Juvenile idiopathic arthritis (JIA) is a complex, multifactorial and chronic inflammatory disease of unknown etiology with considerable variability in which tumor necrosis factor-alpha (TNF-α) plays an important role. Both genetic and environmental factors can contribute to a susceptibility to disease initiation as well as a severity of disease course. TNF-α polymorphisms may be an independent marker of susceptibility and severity of JIA. The aim of this study was to elucidate putative association between the -863 C/A polymorphism in the promoter region of the TNF-a gene and susceptibility to onset and severity of JIA.