Table 1

Etiology of Osteoporosis in Children.

Primary bone disorders
Chronic inflammatory diseases

Osteogenesis imperfecta
Systemic lupus erythematosus

Idiopathic juvenile osteoporosis
Juvenile idiopathic arthritis

Osteoporosis-Pseudoglioma syndrome
Dermatomyositis

Homocystinuria
Inflammatory bowel disease

Ehlers-Danlos syndrome (type I)
Nephrotic syndrome

Marfan syndrome
Immobility or decreased activity

GSD type 1
Post trauma

Juvenile/Early-onset Paget's disease
Cerebral palsy

Catabolic state/Inadequate nutrition/Malabsorption
Spinal muscular atrophy, Muscular dystrophy

Vitamin D deficiency
Medications

Malignancy - Acute lymphoblastic leukemia, Lymphoma
Anticonvulsant, Glucocorticosteroids, Heparin, Methotrexate (in oncology doses)

Cystic fibrosis
Endocrine disorders

Psychiatric eating disorders - Anorexia nervosa/Bulimia
Hypogonadism - Gonadal dysgenesis

Chronic malabsorption (e.g. Celiac disease)
Hyperthyroidism

Acquired immunodeficiency syndrome
Cushing syndrome

Female athlete triad disorder
Growth hormone deficiency


Delayed puberty

Uziel et al. Pediatric Rheumatology 2009 7:16   doi:10.1186/1546-0096-7-16