Table 1 |
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|
Correlation between exposure (12-hour AUC determined by full 10-point PK profile, calculated using the trapezoid rule) and individual time concentration points. |
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|
Parameter |
C0 |
C0.5 |
C1 |
C1.5 |
C2 |
C3 |
C4 |
C6 |
C8 |
C12 |
|
|
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|
Number of XY Pairs |
7 |
7 |
7 |
7 |
7 |
7 |
7 |
7 |
7 |
7 |
|
|
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|
Spearman r |
0.3929 |
0.7500 |
0.2162 |
0.2162 |
0.8571 |
0.7857 |
0.8571 |
0.9190 |
0.6786 |
0.6786 |
|
|
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|
P value (two-tailed) |
0.3956 |
0.0663 |
0.6615 |
0.6615 |
0.0238 |
0.0480 |
0.0238 |
0.0067 |
0.1095 |
0.1095 |
|
|
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|
P value summary |
ns |
ns |
ns |
ns |
* |
* |
* |
** |
ns |
ns |
|
|
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|
Exact or approximate P value? |
Exact |
Exact |
Exact |
Exact |
Exact |
Exact |
Exact |
Exact |
Exact |
Exact |
|
|
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|
Is the correlation significant? (alpha = 0.05) |
No |
No |
No |
No |
Yes |
Yes |
Yes |
Yes |
No |
No |
|
|
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|
Only C6 correlated with AUC. |
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|
Filler et al. Pediatric Rheumatology 2010 8:1 doi:10.1186/1546-0096-8-1 |
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