Table 1 |
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Pediatric Cases of Bulllous SLE |
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Author & Year |
Sex |
Age |
Clinical features |
Histopathological features |
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Jacoby & Abraham 19793 |
Male |
15 years |
Multiple tense vesicles and bullae, arising on normal skin on the face, chest, axilla and inner arm |
Subepidermal blister with neutrophils, eosinophils and lymphocytes. |
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DIF¥ IgG depositis in the BMZ£ under and around the vesicle |
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Hall et al 19824 |
Male |
12 years |
Small vesicles on an erythematous base on arms, face, chest and legs. |
Subepidermal bullae with neutrophilic microabscesses in dermal papillary tips. |
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DIF: linear IgG, IgA, IgM and IgE and granular C3 deposits at the dermo-epidermal junction. |
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Kettler et al 19885 |
Female |
8 years |
Bullous tense eruption over the face, hairline, neck, axilla, groin, ankles, palms and soles. |
Subepidermal bullae with neutrophilic infiltrate as well as papillary microabscesses adjacent to the bulla. |
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DIF: Granular IgG and C3 deposits at the dermo-epidermal junction |
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Roholt et al 19956 |
Female |
9 years |
Linear papulovesicular eruption over the right dorsal hand and ulnar forearm. |
Subepidermal split, mixed cellular infiltrate with neutrophils. |
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DIF: strong IgG, IgA and IgM linear deposition at the dermo-epidermal junction |
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Shirhama et al 19987 |
Female |
9 years |
Widespread blisters on the trunk, neck, and oral mucosa. |
Subepidermal blister with a neutrophilic infiltrate in the upper dermis. |
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DIF: linear IgG, IgA and C3 deposition at the BMZ. |
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Chan et al 19998 |
Female |
15 years |
Numerous tense bulla on her entire skin surface |
Subepidermal blister, neutrophilic infiltrate in papillary dermis and blister cavity. |
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DIF: IgG, IgA and C3 deposits at the BMZ. |
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Nitta Y et al 20029 |
Male |
17 years |
Disseminated blistering eruption |
Papillary microabscesses of neutrophils and subepidermal blisters. |
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DIF: IgG, IgA, IgM and C3 deposits at the BMZ. |
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Harris-Stith et al 200310 |
Female |
17 years |
Photodistributed tense bulla on the face (lips and ears) and upper torso, as well as oral and vaginal erosions |
Neutrophil-rich subepidermal bullae. |
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DIF: IgG, IgM and C3 deposits at the dermo-epidermal junction |
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Sirka et al 200511 |
Female |
18 years |
Vesicles on the left retroauricular area, left upper eyelid, right axilla, chest and abdomen. |
Subepidermal bullae with neutrophilic microabscesses. |
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No DIF was performed. |
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Vijayalkshmi & Jayavardhana 200712 |
Male |
10 years |
Vesicles and bulla on ears, neck, shoulders, arms and legs |
Subepidermal blister with neutrophilic dermal infiltration. |
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DIF: strong IgG and moderately strong IgM, IgA and C3 granular BMZ deposition. |
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Kumar &Agarwal13 |
Female |
13 years |
Numerous bulla and vesicles on the back, abdomen, neck, flexures of the arm and groin. |
Dermo-epidermal separation and a neutrophil-predominant inflammatory infiltrate in the upper dermis. |
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DIF: Prominent fluorescence along the epidermal basement membrane for IgG, IgA, IgM and C3. |
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¥ DIF = Direct Immunofluorescence; £ BMZ= Basal membrane zone |
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Sáez-de-Ocariz et al. Pediatric Rheumatology 2010 8:19 doi:10.1186/1546-0096-8-19 |
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