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Open Access Highly Accessed Review

Post-streptococcal reactive arthritis in children: a distinct entity from acute rheumatic fever

Yosef Uziel1*, Liat Perl1, Judith Barash2 and Philip J Hashkes34

Author Affiliations

1 Pediatric Rheumatology Unit, Pediatric Department, Meir Medical Center, Kfar Saba, Israel and the Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel

2 Pediatric Rheumatology Unit, Ambulatory Day Unit, Kaplan Hospital, Rehovot, Hebrew University, Israel

3 Pediatric Rheumatology Unit, Shaare Zedek Medical Center, Jerusalem, Israel

4 Cleveland Clinic Lerner School of Medicine of Case Western Reserve University, Cleveland, USA

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Pediatric Rheumatology 2011, 9:32  doi:10.1186/1546-0096-9-32

Published: 20 October 2011

Abstract

There is a debate whether post-streptococcal reactive arthritis (PSRA) is a separate entity or a condition on the spectrum of acute rheumatic fever (ARF). We believe that PSRA is a distinct entity and in this paper we review the substantial differences between PSRA and ARF. We show how the demographic, clinical, genetic and treatment characteristics of PSRA differ from ARF. We review diagnostic criteria and regression formulas that attempt to classify patients with PSRA as opposed to ARF. The important implication of these findings may relate to the issue of prophylactic antibiotics after PSRA. However, future trials will be necessary to conclusively answer that question.