1546-0096-6-S1-P11 1546-0096 Poster presentation <p>The TRAF1/C5 region is a risk factor for polyarthritis in juvenile idiopathic arthritis</p> Albers HM Kurreeman FAS Houwing-Duistermaat JJ Brinkman DMC Kamphuis SSM Girschick HJ Wouters C van Rossum MAJ Verduyn W Toes REM Huizinga TWJ Schilham MW ten Cate R

Leiden University Medical Center, Leiden, Netherlands

Erasmus Medical Center – Sophia Children's Hospital, Rotterdam, Netherlands

University of Wuerzburg, Wuerzburg, Germany

University Hospital Gasthuisberg, Leuven, Belgium

Emma Children's Hospital AMC, Amsterdam, Netherlands

 Pediatric Rheumatology <p>15<sup>th </sup>Paediatric Rheumatology European Society (PreS) Congress</p> Wietse Kuis, Patricia Woo, Angelo Ravelli, Hermann Girschick, Michaël Hofer, Johannes Roth, Rotraud K Saurenmann, Alberto Martini, Pavla Dolezova, Janjaap van der Net, Pierre Quartier, Lucy Wedderburn and Jan Scott Meeting abstracts – A single PDF containing all abstracts in this Supplement is available here. <p>15<sup>th </sup>Paediatric Rheumatology European Society (PreS) Congress</p> London, UK 14–17 September 2008 http://www.pres.org.uk 1546-0096 2008 6 Suppl 1 P11 http://www.ped-rheum.com/content/6/S1/P11 10.1186/1546-0096-6-S1-P11 15 9 2008 2008 Albers et al; licensee BioMed Central Ltd.

Background

Juvenile idiopathic arthritis (JIA) is a chronic disorder in which both genetic and environmental factors are involved. Recently we identified the TRAF1/C5 region (located on chromosome 9q33-34) as a risk factor for rheumatoid arthritis (RA) (pcombined = 1.4 × 10-8) 1. In the present study the association of the TRAF1/C5 region with the susceptibility to JIA was investigated.

Methods

A case-control association study was performed in 338 Caucasian JIA patients and 511 healthy individuals. We genotyped SNP rs10818488 as a marker for the TRAF1/C5 region.

Results

The A-allele was associated with the susceptibility to Rheumatoid Factor (RF) negative polyarthritis with an 11% increase in allele frequency (OR 1.54, 95% CI 1.09–2.18; p = 0.012). This association was stronger when combining subtypes with a polyarticular phenotype (OR 1.46, 95% CI 1.12–1.90; p = 0.004). In addition, we observed a trend towards an increase in A-allele frequency in patients with extended oligoarthritis versus persistent oligoarthritis (49% and 38% respectively); p = 0.055.

Conclusion

Apart from being a well replicated risk factor for RA, TRAF1/C5 also appears to be a risk factor for the RF negative polyarthritis subtype of JIA and, more generally, seems to be associated with subtypes of JIA characterized by a polyarticular course.

 <p>A candidate gene approach identifies the TRAF1/C5 region as a risk factor for rheumatoid arthritis</p> Kurreeman FA Padyukov L Marques RB Schrodi SJ Seddighzadeh M Stoeken-Rijsbergen G Helm-van Mil van der AH Allaart CF Verduyn W Houwing-Duistermaat J PLoS Med 2007 4 e278 1976626 17880261 10.1371/journal.pmed.0040278