1546-0096-6-S1-P42 1546-0096 Poster presentation <p>Juvenile Psoriatic Arthritis (JPsA) clinical features and outcome of 119 patients</p> Aviel Y Butbul Tyrrell PN Feldman BM Laxer RM Saurenmann RK Spiegel L Cameron B Tse S Silverman ED

Division of Rheumatology, The Hospital for Sick Children, Department of Pediatrics, University of Toronto, Toronto, Ontario, Canada

 Pediatric Rheumatology <p>15<sup>th </sup>Paediatric Rheumatology European Society (PreS) Congress</p> Wietse Kuis, Patricia Woo, Angelo Ravelli, Hermann Girschick, Michaël Hofer, Johannes Roth, Rotraud K Saurenmann, Alberto Martini, Pavla Dolezova, Janjaap van der Net, Pierre Quartier, Lucy Wedderburn and Jan Scott Meeting abstracts – A single PDF containing all abstracts in this Supplement is available here. <p>15<sup>th </sup>Paediatric Rheumatology European Society (PreS) Congress</p> London, UK 14–17 September 2008 http://www.pres.org.uk 1546-0096 2008 6 Suppl 1 P42 http://www.ped-rheum.com/content/6/S1/P42 10.1186/1546-0096-6-S1-P42 15 9 2008 2008 Aviel et al; licensee BioMed Central Ltd.

Objective

To determine the long-term outcome of a single center cohort of children with JPsA.

Methods

Clinical records of 122 patients meeting the Vancouver or ILAR criteria for JPsA were reviewed. Patients were divided into 4 groups depending on their clinical features: a)Oligoarticular, b)RF(-) polyarticular, c)RF(+) polyarticular and d)enthesitis related arthritis (ERA). Patient characteristics and clinical features at onset and during follow-up were determined.

Results

The cohort consisted of 119 patients, 59(49.6%) had polyarticular course, 54(47.8%) were RF(-) and 4(3.3%) RF(+), 44 patients(38.3%) had oligoarticular course and 16(13.4%) ERA.

At diagnosis patients with ERA were older as compared to patients with oligoarticular and polyarticular course (11.6 ± 2.2 years vs 7.7 ± 4.3 years and 7.1 ± 4.5 years respectively p = 0.001).

Patients with polyarticular course had more MCP, PIP and wrist involvement when compared to patients with oligoarticular course and with ERA (p < 0.001 for all).

Patients with ERA had significantly more hip and sacroiliac involvement compared to the other groups (p < 0.001 for both).

Nail changes was seen in 66 patients (57%) and was associated with DIP involvement at presentation (p = 0.0034).

Outcome

Time to first inactive disease period on but not off therapy was significantly longer among patients with polyarticular disease when compared to the oligoarticular and the ERA groups (p = 0.016 and p = 0.48 respectively).

Patients with polyarticular had more contracture during follow-up when compared to patients with oligoarticular and with ERA (p = 0.01)

Conclusion

Patients with JPsA compromised from three distinct group of patients.

Most patients with JPsA will achieve inactive disease and only minority will have long lasting contracture.